ICG-Maleimide in vascular imaging CAS 2143933-81-5 ICG-Maleimide

The application of ICG-MAL in vascular imaging is mainly through intravenous injection of ICG-MAL and the use of fluorescence imaging equipment, which can observe and assess the hemodynamics of blood vessels, vascular permeability and the status of the blood-brain barrier. Specific applications include the following:

1. Vascular dynamics study: ICG-MAL can be injected into the patient's vein, and the distribution and flow of ICG-MAL in the blood vessel can be observed by fluorescence imaging equipment. This can provide information on the dynamics of the blood vessels, such as blood flow rate, branching of the vessels, etc. For example, ICG-MAL can be used to assess the hemodynamics of cerebral blood vessels and to observe lesions such as blockage or stenosis of blood vessels.

2. Vascular permeability study: ICG-MAL can be injected intravenously into the blood circulation and the distribution of ICG-MAL in the vessel wall and surrounding tissues can be observed by fluorescence imaging equipment. This can provide information on vascular permeability, such as assessing the permeability of the vessel wall and detecting vascular inflammation or injury. For example, ICG-MAL can be used to assess the permeability of tumor blood vessels and to observe abnormalities in tumor vessel walls.

3. Blood-brain barrier studies: ICG-MAL can be used to assess the status and function of the blood-brain barrier. The blood-brain barrier is a special biological barrier that prevents most substances from entering the brain tissue from the bloodstream. The permeability and function of the blood-brain barrier can be assessed by injecting ICG-MAL and observing the passage of ICG-MAL across the blood-brain barrier using fluorescent imaging equipment. For example, ICG-MAL can be used to assess alterations in the blood-brain barrier in neurological disorders such as hydrocephalus and encephalitis.

In summary, the application of ICG-MAL in vascular imaging, mainly by intravenous injection of ICG-MAL and the use of fluorescence imaging equipment, can assess the vascular dynamics, permeability and the status of the blood-brain barrier. It can provide information on vascular dynamics, assess vascular permeability and observe the function of the blood-brain barrier. This information is important for the study of vascular disease, changes in the blood-brain barrier, and the assessment of therapeutic efficacy.